2025 Mercedes-Benz GLS 580 4Matic Review: The Pinnacle of Full-Size Luxury SUV Performance and Refinement
In the fiercely competitive landscape of full-size luxury SUVs, where opulence, capability, and cutting-edge technology converge, the 2025 Mercedes-Benz GLS 580 4Matic stands as a compelling benchmark. Often dubbed the “S-Class of SUVs,” the GLS line has consistently set high standards for what a premium three-row vehicle can offer. Having spent considerable time behind the wheel of the latest GLS 580 on an extensive cross-country evaluation, navigating everything from mundane highway stretches to spirited country roads, I can confidently assert that Mercedes-Benz has once again delivered an automotive masterclass. This isn’t just a vehicle; it’s a sophisticated mobile sanctuary designed to conquer vast distances in unparalleled comfort and style, effortlessly blending potent performance with a truly executive SUV experience.
The proposition of a long-haul journey, say from the industrial heart of Milwaukee to the cultural hub of St. Louis – a six-hour trek often characterized by seemingly endless vistas of agricultural land – transforms entirely when undertaken in the GLS 580. What might otherwise be a monotonous traverse becomes an opportunity to savor the journey itself. The smooth ride, the meticulously crafted and expansive interior, and the sheer
technological prowess of the GLS 580 elevate it beyond mere transportation, solidifying its position as an ideal road-trip companion, especially when shared with good company.
Yet, the GLS 580’s appeal extends far beyond its remarkable capacity for comfortable cruising. It’s an incredibly versatile machine, boasting formidable power, generous seating for up to seven passengers, impressive towing capabilities, and even a surprising aptitude for venturing off the beaten path. This multifaceted excellence, however, comes with a commensurate price tag. With a starting MSRP of $115,950, which includes a $1,150 destination charge, and my extensively optioned test vehicle ringing in at $126,610, the GLS 580 firmly entrenches itself in the upper echelon of the luxury SUV market.
Engineering Marvel: Powertrain and Performance Dynamics
At the heart of the 2025 GLS 580 4Matic lies Mercedes-Benz’s renowned twin-turbocharged 4.0-liter V8 engine, an engineering marvel that embodies German engineering excellence. This powerplant isn’t just powerful; it’s an orchestra of refined might. Here, it churns out a robust 510 horsepower and 538 pound-feet of torque. This internal combustion prowess is seamlessly augmented by a sophisticated 48-volt mild-hybrid system, known as EQ Boost, which contributes an additional 21 horsepower and a significant 184 pound-feet of torque at low RPMs. This integrated system isn’t merely about raw numbers; it dramatically enhances initial acceleration, smooths out power delivery, and enables a more seamless start/stop function, contributing to both responsiveness and efficiency.
The integration of EQ Boost is a testament to Mercedes-Benz’s forward-thinking approach to internal combustion engines, leveraging electrification to optimize traditional powertrains. The system can momentarily fill in torque gaps during gear changes or provide an immediate surge off the line, making the 5,875-pound luxury behemoth feel remarkably agile. On the highway, where I often found myself utilizing only a fraction of its total output – around 30 horsepower and 150 pound-feet for sustained cruising – the deep reserves of power were instantly accessible. When the opportunity arose to overtake a slow-moving semi-truck, a quick tap of the throttle brought the V8 roaring to life with a deep, resonant bellow, as the nine-speed automatic transmission (9G-TRONIC) swiftly dropped gears. This precise and intelligent transmission is a key player, ensuring that the engine is always in its optimal power band, delivering swift, imperceptible shifts that contribute significantly to the vehicle’s refined character. The GLS 580 can sprint from 0 to 60 mph in a mere 4.7 seconds, an astonishing feat for a vehicle of its size, affirming its credentials as a high-performance luxury vehicle.
Power is expertly channeled to all four wheels through Mercedes’ intelligent 4MATIC all-wheel-drive system. This active system constantly monitors traction and distributes torque between the axles, providing unwavering stability and grip in diverse driving conditions, from dry pavement to slick surfaces. The robust V8, coupled with the sturdy 9G-TRONIC transmission and a fundamentally strong unibody structure, also underpins the GLS 580’s impressive towing capacity of up to 7,716 pounds. This substantial figure makes it an ideal choice for those who need to haul a sizeable boat, a horse trailer, or other recreational equipment without compromise, solidifying its position as a truly versatile and capable machine in the premium automotive landscape.
The Art of Motion: Ride, Handling, and Dynamics
The driving experience in the GLS 580 is largely defined by its advanced Airmatic air suspension system, complemented by the Adaptive Damping System Plus (ADS+). This sophisticated setup continuously adjusts each wheel’s damping characteristics in real-time, reacting to road conditions, driving style, and vehicle load. The result is a ride quality that is consistently smooth and supremely comfortable, effectively isolating occupants from the imperfections of the road.
However, the handling characteristics subtly shift depending on the selected drive mode. In “Comfort” mode, the GLS 580 truly floats, prioritizing plushness and ease of travel. With its standard 7.9 inches of ground clearance (adjustable via the air suspension), there’s an inherent sensation of being slightly elevated. While luxurious, this setup can lead to a minor degree of “head toss” for passengers over undulating surfaces or during quick directional changes, as the system prioritizes cushioning over absolute body control. As an expert, I understand this is a deliberate trade-off for maximum comfort, but for drivers who prefer a more buttoned-down feel, there’s a better option.
Switching to “Sport” mode, or configuring an “Individual” mode with Sport handling, transforms the GLS 580’s demeanor. The air springs firm up, the adaptive dampers become more aggressive, and the body roll is significantly reduced. This adjustment drastically improves the vehicle’s composure, making it feel more planted and predictable, especially when navigating curves. While it’s certainly not a sports car – its considerable mass and elevated stature mean it will always lean more than a low-slung sedan – the enhancement in control is palpable. The steering also gains a touch more weight and directness in Sport mode, offering a more engaging connection to the road. For chauffeur duties or simply a more dynamic driving experience, I found Sport mode to be the preferred setting.
While the “Individual” drive mode allows for separate adjustments to steering and stability control, I found minimal practical benefit in altering these from their default settings. There’s no compelling reason to dial back the electronic nannies in a vehicle of this size and weight, particularly when precision and safety are paramount. Compared to body-on-frame competitors like the Cadillac Escalade or Lincoln Navigator, the GLS’s unibody construction provides a distinct advantage, contributing to its lighter feel, superior structural rigidity, and ultimately, a more refined and controlled driving dynamic. The braking system, featuring large, ventilated discs, provides confident and consistent stopping power, essential for managing such a substantial luxury SUV.
Sanctuary on Wheels: Interior Luxury and Advanced Technology
Stepping inside the 2025 Mercedes-Benz GLS 580 4Matic is akin to entering a sophisticated, high-tech sanctuary. The cabin is an exemplary showcase of contemporary luxury, marrying premium materials with an intuitive digital ecosystem. From the driver’s perspective, the experience is immediately elevated. The multi-contour front seats, generously padded and ergonomically designed, offer exceptional support for long journeys. Standard massaging functions and plush head pillows further enhance comfort, transforming extended drives into genuinely relaxing experiences. While these features were a personal highlight for me, it’s a reminder of individual preferences that my long-time friend found them somewhat intrusive – proving there’s truly no accounting for taste!
Central to the cabin’s technological prowess is the Mercedes-Benz User Experience (MBUX) infotainment system, displayed across a stunning 12.3-inch touchscreen. This system is widely regarded as one of the industry’s finest, boasting rapid response times, crystal-clear graphics, and an intuitive interface. Switching between satellite radio, Apple CarPlay, or Android Auto is seamless, executed with either a touch, the steering wheel controls, or the haptic trackpad located on the center console. While the trackpad offers an alternative input method, its placement does occupy valuable real estate that some might prefer dedicated to additional storage. Complementing the central screen is a equally impressive 12.3-inch digital instrument cluster, which is highly customizable, offering a wealth of driver-centric information displayed across various themes – from classic gauges to full-map navigation views.
Connectivity is paramount in a modern luxury vehicle, and the GLS 580 delivers. Wireless Apple CarPlay and Android Auto are standard, alongside a wireless charging pad and numerous USB-C ports strategically placed throughout the cabin. A Wi-Fi hotspot keeps all passengers connected. The Burmester surround sound system, a hallmark of Mercedes-Benz luxury, provides an immersive audio experience, turning the cabin into a concert hall on wheels. Furthermore, the 64-color ambient lighting system allows occupants to personalize the cabin’s mood, casting a soft, customizable glow that elevates the nighttime driving experience.
When it comes to driver-assistance systems, the GLS 580 offers an extensive suite designed to enhance safety and reduce driver fatigue. Its adaptive cruise control (DISTRONIC) with active steering assist and lane-keeping assist performs admirably, maintaining distance and keeping the vehicle centered in its lane. However, these are Level 2 systems, requiring the driver to keep hands on the wheel, unlike GM’s Super Cruise or Ford’s BlueCruise. Mercedes-Benz does offer its more advanced Level 3 Drive Pilot system, which permits true hands-free driving under specific conditions, but its deployment is currently limited to certain Western states and primarily on the S-Class and EQS models. While the GLS 580’s current suite is highly capable, the anticipation for widespread Level 3 integration remains a point of interest for future iterations of this premium automotive technology.
Uncompromising Utility: Space, Versatility, and Off-Road Prowess
The GLS 580 excels not only in luxury and performance but also in practical utility. Its spacious cabin comfortably accommodates up to seven occupants. During my travels with up to five passengers, the vehicle effortlessly absorbed both people and their gear. The second-row captain’s chairs provide individual bucket-seat comfort, offering more than ample legroom and headroom for adult passengers. These seats are also heated, and occupants can manage their climate zones via a dedicated display screen with tactile hard buttons, underscoring the sophisticated interior design and attention to passenger well-being.
Even the third row, often an afterthought in many SUVs, is genuinely usable for two adults. The bottom cushion sits high enough to provide decent thigh support, and a six-footer will find sufficient headroom. Legroom can become snug if exceptionally tall individuals occupy all three rows simultaneously, but for most families, the third row is a highly functional space, complete with its own climate zone. Access to the third row, however, is primarily facilitated by the passenger-side second-row seat, which tilts and slides forward. Some passengers expressed a desire for both second-row seats to offer this functionality, and also noted that the standard running boards, while aesthetically integrated, were tucked in too tightly to the body to be truly useful as steps.
Cargo capacity is robust and flexible. Behind the third row, the GLS 580 offers a modest 17.4 cubic feet of space – enough for a few carry-on bags. However, with the third row power-folded flat, capacity expands to a very useful 48.7 cubic feet. Folding both the second and third rows flat creates an impressive 84.7 cubic feet of cavernous space, easily accommodating large items like bicycles or substantial camping gear. The power-operated tailgate and seat-folding mechanisms emphasize the vehicle’s commitment to convenience.
Beyond its on-road prowess, the GLS 580 possesses a surprising degree of off-road capability. The standard Airmatic air suspension can raise the ground clearance, providing a few extra inches in “Off-road” mode to clear obstacles. Mercedes-Benz further aids off-roading with an “Off-road Cockpit” screen, which displays critical information such as individual wheel height, tire pressure and temperature, and steering angle. Innovative forward and “transparent hood” camera views allow drivers to see what’s directly ahead of and even beneath the vehicle, a genuinely useful feature for navigating tricky terrain. However, the factory-fitted 285/45R22 front and 325/40R22 rear Continental EcoContact6 Q MO tires, while excellent for ride quality and highway quietness, are optimized for pavement and would be the limiting factor for serious off-road excursions. For extreme adventures, a different tire choice would be recommended.
Fuel Efficiency and Ownership Considerations
Given its substantial size, powerful V8 engine, and luxury appointments, fuel economy is not the GLS 580’s primary selling point. The EPA rates it at 14 mpg in the city, 19 mpg on the highway, and 16 mpg combined. My real-world experience over 950 miles, which involved a mix of highway cruising and some city driving, yielded a respectable average of 19.4 mpg – slightly better than the official highway rating, a testament to the efficiency gains from the EQ Boost system and the intelligent 9G-TRONIC transmission.
Ownership of a premium automotive product like the GLS 580 naturally entails considerations beyond the initial purchase price. Factor in luxury vehicle insurance, routine maintenance, and the potential for specialized service. However, for those seeking the ultimate combination of performance, opulence, and family-friendly utility in a full-size luxury SUV, the investment is justified by the vehicle’s unparalleled blend of features and the prestige associated with the Mercedes-Benz badge.
Conclusion: Redefining the Full-Size Luxury SUV Experience
The 2025 Mercedes-Benz GLS 580 4Matic unequivocally reaffirms its status as the “S-Class of SUVs.” It is a meticulously engineered machine that effortlessly balances potent V8 performance with the serene comfort and technological sophistication expected of a flagship luxury vehicle. From its seamlessly integrated mild-hybrid powertrain to its exquisitely appointed cabin and adaptable chassis, every aspect of the GLS 580 is designed to deliver a superlative driving and passenger experience.
It excels as a long-distance cruiser, a capable family hauler, and even possesses an adventurous spirit for light off-road exploration. While minor critiques regarding running board practicality or the current limitations of its Level 3 driver-assist technology exist, these are overshadowed by the vehicle’s overwhelming strengths. The GLS 580 represents the zenith of full-size luxury, making it an ideal choice for discerning buyers who demand uncompromising quality, performance, and versatility. It doesn’t just transport; it transforms the act of travel, redefining what an executive SUV can achieve in the modern luxury landscape.
